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I was taking Prozac (fluoxetine hydrochloride) for 10yrs to treat PMDD, postpartum depression, OCD. since I stopped this and started sertraline I realized the Prozac was weak in helping me! Sertraline's amazing! It has helped settle my major symptoms of illnesses above, I now live a normal life and everything isn't such a big deal to me anymore. I'm more rational and certainly don't turn into a monster in menstrual cycle. I'm much more calm and collected! Side effects I suffered sleepiness and irritability and dry mouth in the 1st week, that stopped. I persisted was going to stop thankfully I didn't! I have noticed as I have been on them 3 months now I have a decreased appetite, indigestion, slower digestive system which I can tolerate! Sometimes hyperactivity.
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Pearson correlation analysis was used to examine associations of the pre-treatment levels of tryptophan pathway metabolites and ratios to the percent change in HAMD 17 scores after four weeks of treatment.

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After open-label sertraline, one subject reported complete resolution, and the remainder all reported improvement in their pruritus.

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Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment.

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At least 14 days should elapse between discontinuation of an MAOI and initiation of therapy with sertraline hydrochloride.

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Because I took other SSRI's which did not cause me to have side effects such as this one, I would prefer not to try and see how long it takes for sertraline to reach full efficacy.

Low-quality evidence also showed no difference in discontinuation due to adverse events when switching from 1 SGA (citalopram) to another (sertraline, bupropion, or venlafaxine) compared with switching to cognitive therapy ().

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It is not known how or why these patients are apparantly made more suicidal when taking SSRI's, but some people have suggested that it may have to do with the way different individuals metabolize the SSRI's.

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Wort is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases.

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Taking an SSRI antidepressant during pregnancy may cause serious lung problems or other complications in the baby.

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